You should not take quinine if you have a heart rhythm disorder called Long QT syndrome, a genetic enzyme deficiency called glucose-6-phosphate dehydrogenase deficiency (G-6-PD), myasthenia gravis, optic neuritis (inflammation of the nerves in your eyes), if you have taken quinine in the past and it caused a blood cell disorder or severe bleeding. It may result in heart rhythm disturbances, serious allergic reactions or a dangerous blood disorder. Quinine is a medication used to treat malaria and babesiosis. Chemists later determined that the active ingredient in this healing bark was quinine, and it was used around the world wherever mosquitoes carried the disease. The US Food and Drug Administration (FDA) decided that because leg cramping was more of an annoyance than a life-threatening illness - and that taking quinine for leg cramping could prove fatal - that the risk clearly outweighed the benefits. The agency decided that quinine was too dangerous for people to take without medical supervision. Quinine will not treat severe forms of malaria, and it should not be taken to prevent malaria. Take with food if quinine upsets your stomach. In Europe, this bark proved useful for treating the fever and chills of malaria. The licensed dose for the treatment and prevention of nocturnal leg cramps in adults is 200–300 mg at night for quinine sulphate (recommended starting dose 200 mg), and is 300 mg at night for the bisulphate. For years, people bought this drug in over-the-counter products such as Legatrin, Q-vel and Quinamm to relieve muscle cramps. Why would the Food and Drug Administration ban quinine? A glass of tonic water would provide about 20 mg, one tenth of the dose. However, despite its side effects, quinine was preferred as a remedy for leg cramps until 1994, when the US government banned the use of quinine except in the treatment of malaria. What can people do? Terry Graedon, PhD, is a medical anthropologist and co-host of The People’s Pharmacy radio show, co-author of The People’s Pharmacy syndicated newspaper columns and numerous books, and co-founder of The People’s Pharmacy website. Over the years, more than 90 people have died of quinine complications. Quinine systemic 325 mg (MUTUAL 102 MUTUAL 102). Quinine is FDA-approved for the treatment of uncomplicated Plasmodium falciparum malaria. The agency decided that quinine was too dangerous for people to take without medical supervision. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. In British colonial times, tonic water had a much higher quinine content … Do not purchase quinine on the Internet or from vendors outside of the United States. As a matter of fact, the FDA prohibits marketing Quinine for leg cramps and requires a warning against using the drug to treat leg cramps. These remedies appear to be safer than quinine, and possibly even better than tonic water. On December 12, 2006, the FDA ordered unapproved quinine drug products to be removed from the market and cautioned consumers about the off-label use of quinine … The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Do not give this medication to a child younger than 16 years old. Stop taking quinine and call your doctor at once if you have headache with chest pain and severe dizziness, fast or pounding heartbeats, unusual bruising or bleeding (nosebleeds, bleeding gums, purple or red spots under your skin), signs of infection (fever, chills, mouth sores), severe lower back pain, or blood in your urine. It has not been approved by the Food & Drug Administration (FDA) for use in the treatment of leg cramps. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Quinine, when found in small doses in tonic water, is safe to consume. Also, quinine is dangerous if it is taken by a child, so keep the tablets away from children. Even a small amount might be sufficient to stop leg cramps quickly. When used as a drug, why is quinine now banned? What a relief to be able to finally get a good night’s sleep!”. Quinine is a drug used to treat malaria, but some firms have been marketing “off label” for treatment of leg cramps. For years, quinine was available in drugstore products to relieve muscle cramps, but the FDA has now banned it for this use. He takes one pill each night before bedtime and gets wonderful results.”. Tell your doctor if you are breast-feeding a baby. Quinine comes from the Cinchona tree, named as all good things are after a woman. Quinine drug interactions (in more detail). As of December 2006, Qualaquin is the only brand of quinine that is approved by the FDA. Generic Name: quinine (KWYE nine)Brand Name: Qualaquin, QM-260, Quinamm, Medically reviewed by Drugs.com on Mar 25, 2020 – Written by Cerner Multum. Not all possible interactions are listed here. The FDA banned quinine for preventing leg cramps because the drug can cause potentially lethal reactions. Quinine can cause serious or life-threatening side effects, and is approved for use only in treating malaria. This includes the treatment of malaria due to Plasmodium falciparum that is resistant to chloroquine when artesunate is not available. Quinine may cause blurred vision and may impair your thinking or reactions. In 1994 the FDA banned quinine from over-the-counter sale. Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Parasites that cause malaria typically enter the body through the bite of a mosquito. The FDA banned red yeast rice for absolutely no good reason (or at least red … The drug should only be used to treat Malaria. There is recent evidence to support the FDA’s decision to limit quinine prescriptions. The U.S. Food and Drug Administration has banned the sale of all non-approved brands of quinine because of the risk of serious side effects or death. Quinine can pass into breast milk and may harm a nursing baby. The quinine salt should always be stated when prescribing because 200 mg quinine sulphate is equivalent to around 300 mg quinine bisulphate. Last Updated: June 23, 2020 The U.S. Food and Drug Administration has banned the sale of all non-approved brands of quinine. A: Many people do well with quinine… Doctors continued to prescribe quinine sulfate for restless legs as well as leg cramps. Do not purchase … The bark of the cinchona tree yielded quinine, which quickly became popular throughout Europe for treating fevers. Version: 9.01. doxycycline, clindamycin, hydroxychloroquine, Plaquenil, Cleocin. The FDA proposed a ban on over-the-counter sales of hydroquinone-containing products on August 29, 2006. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Avoid taking other anti-malaria medications without your doctor's advice. A dilute source of quinine can be found in grocery stores, Quinine is added to tonic water in very small quantities to produce the bitter taste that is enjoyed in some alcoholic drinks. But quinine was popular as a treatment for nighttime leg cramps. The British even incorporated it into their “tonic water.”. In fact, the FDA has banned all but one brand of quinine, Qualaquin, for medicinal use. Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. This list is not complete and many other drugs can interact with quinine. Call your doctor for medical advice about side effects. Terry taught in the Duke University School of Nursing and was an adjunct assistant professor in the Department of Anthropology. These work through the same TRP channels that we think are responsible for the quinine effect. Quinine can pass through the placenta from mother to fetus and there is some limited evidence that it can cause birth defects, so pregnant women should avoid the … severe skin reaction -- fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling. Avoid using antacids without your doctor's advice. Other approaches to nocturnal leg cramps include drinking low-sodium V-8 juice, consuming extra calcium, magnesium and B vitamins. The 2nd countess of Chinchon in Peru c.1742. Tonic water is a soft drink containing quinine, which gives it a bitter taste. tuberculosis medication--rifabutin, rifampin, rifapentine. Your symptoms may get better before your condition is completely cleared. Nothing kept me from having to get up and massage my feet and legs until I tried the soap. You may report side effects to FDA at 1-800-FDA-1088. Quinine is currently approved only for the treatment of malaria in the U.S. Quinine is used to treat uncomplicated malaria, a disease caused by parasites. The U.S. Food and Drug Administration has banned the sale of all non-approved brands of quinine. She is a Fellow of the Society of Applied Anthropology. Self-medication using quinine can be extremely risky, so see your doctor for treatment of conditions where quinine may be prescribed. One popular remedy is pickle juice or pickle relish. Quinine is a drug traditionally used to treat Malaria. Pfizer Pharmaceuticals had been selling the brand name Legatrin for this purpose. However, after discovering that quinine could cause conditions such as arrhythmia (irregular heartbeat), lowered platelet count, and even hypersensitivity to other drugs, this drug was banned by the FDA for the treatment of leg cramps. Be careful if you drive or do anything that requires you to be alert and able to see clearly. Quinine is present in drinks such as tonic water and bitter lemon. Many drugs can interact with quinine. If a pregnant woman took quinine, her baby could be born with a defect. Select one or more newsletters to continue. But quinine was popular as a treatment for nighttime leg cramps. The FDA then banned quinine … Quinine is a common treatment for malaria. Because a liter bottle of tonic water contains only 83 mg of quinine, drinking tonic water provides far less of this compound. Data sources include IBM Watson Micromedex (updated 7 Dec 2020), Cerner Multum™ (updated 4 Dec 2020), ASHP (updated 3 Dec 2020) and others. Call your doctor if your symptoms do not improve after 2 days of treatment, or if your symptoms return after you have finished the medicine. Even before the Spanish discovered the New World, native healers in Peru were using the bark of the cinchona tree to treat fever, malaria and indigestion. We discuss a number of home remedies and other approaches to this common problem in our Guide to Leg Pain. One reader had good results from an inexpensive remedy: “After suffering with leg cramps for over 30 years, I heard about putting a bar of soap under the bottom sheet of the bed. While it was once used to manage painful, nocturnal (night time) leg cramps, the FDA banned over-the-counter sales of this compound because it has potential to be misused, is not always effective and can cause side effects. Some people have used quinine to treat leg cramps, but this is not an FDA-approved use. The Quechua people of Peru used the bark of the Cinchona to prevent shivering by creating a mix of ground bark with a sweetened water thus producing tonic water. Only one brand of quinine was allowed on the market. Do not take extra medicine to make up the missed dose. Some people have found, however, that drinking tonic water can alleviate leg cramps, especially those that occur at night. Available for Android and iOS devices. The first tonic waters contained powdered quinine, sugar, and soda water. The FDA maintains that leg cramps are not a serious health problem, while quinine can be lethal. Q. I have suffered with nocturnal leg cramps for many years. headache, blurred vision, changes in color vision; sweating or flushing (warmth, redness, or tingly feeling); mild dizziness, spinning sensation, ringing in your ears; or. Dec. 12, 2006 -- The FDA is telling people not to use the malaria drug quinine for leg cramps, citing potentially deadly side effects. Take the missed dose as soon as you remember. However, its continued use is challenged by its poor tolerability, poor compliance with complex dosing regimens, and the availability of more efficacious anti-malarial drugs. In 1994, the FDA banned the use of over-the-counter (OTC) quinine as a treatment for nocturnal leg cramps. An Augustinian monk wrote about the uses of the “fever tree” back in 1633. Do not purchase quinine on the Internet or from vendors outside of the United States. While sometimes used for restless legs syndrome, quinine is not recommended for this purpose due to the risk of serious side effects. We comply with the HONcode standard for trustworthy health information -. If you need surgery or medical tests, tell your caregivers ahead of time that you are using quinine. Although there aren’t very many other medications that can relieve leg cramps, there are a number of home remedies that can help. Quinine may also be used for purposes not listed in this medication guide. Doctors used to prescribe 200 to 300 mg of quinine for nighttime leg cramps. Drinking tonic water is generally considered safe, but there are some people who need to avoid it completely. A. For years, people bought this drug in over-the-counter products such as Legatrin, Q-vel and Quinamm to relieve muscle cramps. Cinchona contains quinine, which was banned by the U.S. Food and Drug Administration (FDA) from sale over-the-counter for treatment of leg muscle cramps because it caused serious side effects. The FDA has issued warnings about quinine since 1994 and more recently about its minimal effectiveness in treating leg cramps. Every evening I have a large glass of tonic water and have no more cramps! Why does the FDA warn against the use of quinine to treat or prevent leg cramps and related conditions? Use only the type of antacid your doctor recommends. Quinine remains an important anti-malarial drug almost 400 years after its effectiveness was first documented. Why would the Food and Drug Administration ban quinine when it is the only thing that works? You can learn more about this fascinating explanation by listening to our interview with neuroscientist Bruce Bean. Malaria is common in areas such as Africa, South America, and Southern Asia. FDA pregnancy category C. It is not known whether quinine will harm an unborn baby. Give a list of all your medicines to any healthcare provider who treats you. To make sure quinine is safe for you, tell your doctor if you have: heart disease or a heart rhythm disorder; low potassium levels in your blood (hypokalemia); or. I spend most of the night pacing the floor to work out the cramps. On December 11, 2006, the FDA banned all over the counter products containing quinine sulfate, a drug used for centuries to treat malaria, but which has also been widely used to treat leg cramps and muscle spasms. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. This includes prescription and over-the-counter medicines, vitamins, and herbal products. In 1994 the FDA banned quinine from over-the-counter sale. Quinine is used to treat uncomplicated malaria, a disease caused by parasites. Store at room temperature away from moisture and heat. A study found that British people taking at least 100 mg of a quinine compound daily for a year were more likely to die during the five year follow-up period (Fardet, Nazareth & Petersen, JAMA, May 9, 2017). some people who need to avoid it completel, our interview with neuroscientist Bruce Bean. fever, chills, body aches, flu symptoms, sores in your mouth and throat; easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin; headache with chest pain and severe dizziness, fainting, fast or pounding heartbeats; sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech, problems with balance; chest pain, sudden cough, wheezing, rapid breathing, coughing up blood; pain, swelling, warmth, or redness in one or both legs; severe pain in your side or lower back, blood in your urine, little or no urine; low blood sugar (more common in pregnant women)--headache, hunger, weakness, sweating, confusion, irritability, dizziness, fast heart rate, or feeling jittery; loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or. 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